7144287
WDFY3 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
WDFY3
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
ALFY, autophagy-linked FYVE protein, KIAA0993, ZFYVE25
Gene Symbols
WDFY3
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q8IZQ1
Gene ID (Entrez)
23001
Immunogen
Between 500 and 550
Primary or Secondary
Primary
Content And Storage
4° C
Gene
WDFY3
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Pig, Orangutan, Gorilla, Chimpanzee, Northern white-cheeked gibbon, Little brown bat Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation
- Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures)
- May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate
- The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance
- Involved in midbody ring degradation.