7144500
SET7 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
SET7
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
Set7/9
Gene Symbols
SETD7
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q8WTS6
Gene ID (Entrez)
80854
Immunogen
Between 316 and 366
Primary or Secondary
Primary
Content And Storage
4° C
Gene
SETD7
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Dog, Horse, Rabbit, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee and Sm Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3
- H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation
- Plays a central role in the transcriptional activation of genes such as collagenase or insulin
- Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription
- Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins
- Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II
- Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation
- Also able to demethylated 'Lys-372' of p53/TP53 in vitro.