7188677
Sp1 Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Sp1
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P08047
Gene ID (Entrez)
6667
Immunogen
This Sp1 antibody was raised against a peptide containing serine 101 of human Sp1.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
SP1
Concentration
Lot-Specific
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
1110003E12Rik; AA450830; AI845540; HGNC:11205; Sp1; Sp1 transcription factor; Sp1-1; Specificity protein 1; trans-acting transcription factor 1; Transcription factor Sp1; TSFP1
Gene Symbols
SP1
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Related Products
Description
- SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli
- Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses
- Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation)
- Binds also the PDGFR-alpha G-box promoter
- May have a role in modulating the cellular response to DNA damage
- Implicated in chromatin remodeling
- Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter
- Plays an essential role in the regulation of FE65 gene expression.