MITF Monoclonal Antibody (C5.D5), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
MITF
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
BCC2; BHLHE32; black eyed white; BOS_20839; Bw; Class E basic helix-loop-helix protein 32; CMM8; Gsfbcc2; melanocyte inducing transcription factor; melanogenesis associated transcription factor; Mi; microphtalmia-associated transcription factor; microphthalmia transcription factor; Microphthalmia-associated transcription factor; microphthalmia-associated transcription factor A; microphthalmia-associated transcription factor isoform H protein; microphthalmia-associated transcription factor Trnc-1; microphthalmia-associated transcription factor Trnc-2; microphthalmia-associated transcription factor variant 1; microphthalmia-associated transcription factor variant 2; microphthalmia-associated transcription factor variant 3; microphthalmia-associated transcription factor variant MITF-M(+); MITF; MITF-H; MITF-M; transcription factor, isoform 7; Vit; Vitiligo; Wh; WS2; WS2A
Gene Symbols
MITF
Isotype
IgG1
Purification Method
Protein G
Product Type
Antibody
Clone
C5.D5
Applications
ChIP Assay, ChIP sequencing (ChIP-seq)
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
O75030
Gene ID (Entrez)
4286
Immunogen
This MITF antibody was raised against an N-terminal fragment of human MITF.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
MITF
Related Products
Description
- Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development
- The mutation of Mi causes Waardenburg Syndrome type II in humans
- In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells
- There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus
- Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, while the longer Mi form runs as a cluster of bands at 60-70 kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.