7188753
Histone H3S10ph Monoclonal Antibody (6G8B7), Active Motif™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Histone H3S10ph
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Isotype
IgG2a
Purification Method
Protein G
Product Type
Antibody
Clone
6G8B7
Applications
ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate
Unconjugated
Host Species
Rat
Target Species
Human
Immunogen
This antibody was raised against a peptide corresponding to amino acids 1-19 including phospho-serine 10 of human Histone H3.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
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Description
- Description Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells
- H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome
- Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability
- Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors
- The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modifications that influence cellular processes
- These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.