AIB3 Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
AIB3
Applications
Immunohistochemistry, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
Q14686, Q9JL19
Gene ID (Entrez)
23054, 56406
Immunogen
This AIB3 antibody was raised against a recombinant protein corresponding to amino acids 22-146 of mouse AIB3.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
NCOA6
Concentration
Lot-Specific
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris HCl with 1% BSA, 105mM NaCl, 30% glycerol, 70mM glycine and 0.035% sodium azide; pH 8
Gene Alias
Activating signal cointegrator 2; activating signal cointegrator-2; AIB3; Amplified in breast cancer protein 3; amplified in breast cancer-3 protein; ASC2; ASC-2; Cancer-amplified transcriptional coactivator ASC-2; KIAA0181; mKIAA0181; NCOA6; Ncoa7; NRC; NRC RAP250; Nuclear receptor coactivator 6; Nuclear receptor coactivator RAP250; nuclear receptor-activating protein 250; Nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein; peroxisome proliferator-activated receptor interacting protein,PRIP; Peroxisome proliferator-activated receptor-interacting protein; PPAR interacting protein PRIP; PPAR-interacting protein; PRIP; RAP250; thyroid hormone receptor binding protein; Thyroid hormone receptor-binding protein; TRBP
Gene Symbols
NCOA6
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Related Products
Description
- Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion
- Coactivates expression in an agonist- and AF2-dependent manner
- Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs)
- Probably functions as a general coactivator, rather than just a nuclear receptor coactivator
- May also be involved in the coactivation of the NF-kappa-B pathway
- May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.