CtIP Monoclonal Antibody (14-1), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CtIP
Concentration
1 mg/mL
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
Q99708
Gene ID (Entrez)
5932
Immunogen
This CtIP antibody was raised against a recombinant protein corresponding to amino acid residues 620-897 of human CtIP.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
Rbbp8
Clone
14-1
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
9930104E21Rik; COM1; CtBP-interacting protein; Ctip; DNA endonuclease RBBP8; JWDS; RB binding protein 8, endonuclease; Rbbp8; RBBP-8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RGD1308872; RIM; SAE2; SCKL2; Sporulation in the absence of SPO11 protein 2 homolog
Gene Symbols
Rbbp8
Isotype
IgG1
Purification Method
Protein A
Product Type
Antibody
Related Products
Description
- CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription
- Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor
- This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation
- Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.