JMJD3 / KDM6B Monoclonal Antibody (67-A2), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
JMJD3 / KDM6B
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
1700064E03Rik; BC038313; JmjC domain-containing protein 3; Jmjd3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jumonji domain-containing 3; Jumonji domain-containing protein 3; KDM1 lysine (K)-specific demethylase 6B; Kdm6b; Kiaa0346; lysine (K)-specific demethylase 6B; Lysine demethylase 6B; Lysine-specific demethylase 6B; mKIAA0346
Gene Symbols
KDM6B
Isotype
IgG1
Purification Method
Protein A
Product Type
Antibody
Clone
67-A2
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse
Gene Accession No.
O15054, Q5NCY0
Gene ID (Entrez)
216850, 23135
Immunogen
This antibody was raised against a recombinant protein corresponding to amino acids 1028-1684 of human JMJD3 / kDM6B.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
KDM6B
Related Products
Description
- Covalent modification of histones plays critical role in regulating chromatin structure and transcription
- While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones
- A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function
- Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate
- Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9)
- Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.