7193263
B7-H6 Monoclonal Antibody (JAM1EW), PE, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
B7-H6
Concentration
5 μL/Test
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Alias
B7 homolog 6; B7H6; B7-H6; DKFZp686I21167; DKFZp686O24166; natural cytotoxicity triggering receptor 3 ligand 1; natural killer cell cytotoxicity receptor 3 ligand 1; NCR3LG1; putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167
Gene Symbols
NCR3LG1
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Clone
JAM1EW
Applications
Flow Cytometry
Conjugate
PE
Host Species
Mouse
Target Species
Human
Gene Accession No.
Q68D85
Gene ID (Entrez)
374383
Immunogen
B7-H6 recombinant protein
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Gene
NCR3LG1
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Description
- Description: This JAM1EW monoclonal antibody recognizes human B7-H6 (NCR3LG1) protein on the surface of cells
- It recognizes protein on live but not on paraformaldehyde-fixed cells
- The JAM1EW clone is specific to B7-H6
- When tested in flow cytometry against cells transfected with either B7-H4, B7-H5, B7-H6, or B7-H7, clone JAM1EW only stains positively on B7-H6 transfected cells
- Applications Reported: This JAM1EW antibody has been reported for use in flow cytometric analysis
- Applications Tested: This JAM1EW antibody has been pre-diluted and tested by flow cytometric analysis of HeLa and HL-60 cell line
- This may be used at 5 μL (0.25 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser B7-H6 (NCR3LG1) is a transmembrane endogenous ligand expressed on the surfaces of tumor cells
- B7-H6 binds with NKp30 present on NK cells
- Binding of B7-H6 to NKp30 causes the ligation of NKp30 subsequently inducing NK cell activation and target cell cytolysis
- B7-H6 is not constitutively expressed on normal tissue
- Whether it can be expressed endogenously under certain conditions is under investigation
- B7-H6 has been detected on circulating pro-inflammatory CD14(+)CD16(+) monocytes in some patients with sepsis.