GFI1b Polyclonal Antibody, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 72-034-4-Each-of-1 | In Stock | ₹ 38,270.00 |
72-034-4 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,270.00
GST (18%): ₹ 6,888.60
Total Price: ₹ 45,158.60
Antigen
GFI1b
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GFI1B
Gene Alias
BDPLT17; GFI1B; Gfi-1B; growth factor independent 1B; growth factor independent 1B (potential regulator of CDKN1A, translocated in CML); growth factor independent 1B transcription repressor; growth factor independent 1B transcriptional repressor; growth factor independent 1B-like protein; growth factor independent protein 1B; growth factor-independent 1B; Potential regulator of CDKN1A translocated in CML; Zinc finger protein Gfi-1b; ZNF163B
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
8328
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.1% BSA, 30% glycerol and 0.09% sodium azide; pH 7.4
Gene Accession No.
Q5VTD9
Gene Symbols
GFI1B
Immunogen
Protein corresponding to human GFI1b (aa21-aa170)
Quantity
100μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with Monkey, Horse, Pig, Goat
- GFI1b (zinc finger protein GFI-1b) is an essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages
- It is also a component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation
- GFI1b also acts as a transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways
- It also cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate
- Mutations affecting the gene are associated with Bleeding disorder, platelet-type 17 (BDPLT17).