LAG-3 Antibody (C9B7W) - BSA Free, Novus Biologicals™

LAG-3

1.0 mg/mL

Flow Cytometry

Unconjugated

Rat

Adaptive Immunity, Immunology, Innate Immunity

Q61790

3902

Murine CD223 Ig fusion protein

Primary

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

57 kDa

C9B7W

Flow Cytometry 1:50 - 1:200

Monoclonal

Purified

RUO

Mouse

CD223, CD223 antigen, FDC, LAG-3, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3, Protein FDC

LAG3

IgG1

Protein G purified

NB100-63601 recognizes murine lymphocyte activation gene-3 (LAG-3), a 70kD activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognizes an epitope within the D2 domain of CD223. The antibody is reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II (1). 1. Workman, C.J. et al. (2002) Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur J Immunol. 32 (8): 2255-63