Phospho-PKC alpha (Thr497) Recombinant Rabbit Monoclonal Antibody (PKCaT497-F1), PE, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Phospho-PKC alpha (Thr497)
Applications
Flow Cytometry
Conjugate
PE
Host Species
Rabbit
Target Species
Human, Mouse, Rat
Gene Accession No.
P05696, P17252, P20444
Gene ID (Entrez)
18750, 24680, 5578
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr497 of human phospho PKC alpha.
Primary or Secondary
Primary
Content And Storage
4° C
Gene
PRKCA
Clone
PKCaT497-F1
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias
AAG6; aging-associated gene 6; AI875142; EC 2.7.11.13; FHC; FTH; FTHL6; im:7139045; kinase PKC-alpha; KPCA; MGC104426; PIG15; PKC III; Pkca; PKC-A; PKC-alpha; PKC-III; PKRCA; PLIF; PRKACA; Prkca; prkcaa; protein kinase C; protein kinase C alpha; protein kinase C alpha type; protein kinase C alpha type; protein kinase C, alpha, a; protein kinase C, alpha; protein kinase C, alpha, a; protein kinase c-alpha; si:dkey-8l19.1; Unknown (protein for IMAGE:7139045); unnamed protein product
Gene Symbols
PRKCA
Isotype
IgG κ
Purification Method
Protein A/G
Product Type
Antibody
Related Products
Description
- Description The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways
- In humans, at least 12 different PKC polypeptides have been identified
- These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity
- PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent
- Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol
- PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways
- PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters
- Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells
- The protein encoded by this gene is one of the PKC family members
- This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control
- Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.