Phospho-PKC gamma (Thr514) Recombinant Rabbit Monoclonal Antibody (PKCgT514-PF4), Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA537440-Each-of-1 | In Stock | ₹ 33,019.00 |
PIMA537440 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,019.00
GST (18%): ₹ 5,943.42
Total Price: ₹ 38,962.42
Antigen
Phospho-PKC gamma (Thr514)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
P05129, P63318, P63319
Gene Symbols
PRKCG
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr514 of human phospho PKC gamma.
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG κ
Applications
Flow Cytometry, Western Blot
Clone
PKCgT514-PF4
Conjugate
Unconjugated
Gene
PRKCG
Gene Alias
PKC; Pkcc; PKCG; PKCgamma; PKC-gamma; PKCI; Prkc; Prkcc; PRKCG; protein kinase C gamma; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma; RATPKCI; SCA14
Host Species
Rabbit
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
18752, 24681, 5582
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways
- In humans, at least 12 different PKC polypeptides have been identified
- These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity
- PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent
- Protein kinase C can be activated by calcium and second messenger diacylglycerol
- PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways
- PKC also serve as major receptors for phorbol esters, a class of tumor promoters
- Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells
- PKC gamma is one of the PKC family members
- This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons
- It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase
- Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development
- Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).