7218780
EOMES Monoclonal Antibody (Dan11mag), APC, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
EOMES
Concentration
0.2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
C77258; EOMES; eomesodermin; eomesodermin homolog; eomesodermin homolog (Xenopus laevis); T-box brain protein 2; T-box transcription factor; TBR2; TBR-2; T-brain-2
Gene Symbols
Eomes
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Gene
Eomes
Clone
Dan11mag
Applications
Flow Cytometry
Conjugate
APC
Host Species
Rat
Target Species
Mouse
Gene Accession No.
O54839
Gene ID (Entrez)
13813
Isotype
IgG2a κ
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- This Dan11mag antibody recognizes Eomesodermin (EOMES), also known as T-box brain 2 (TBR2)
- Eomes is a T-box transcription factor that is highly homologous to T-bet, which is essential during trophoblast development and gastrulation in most vertebrates
- In the immune system, Eomes controls the differentiation of effector and memory CD8+ T cells, as well as natural killer (NK) cells
- Expression of Eomes in these cells correlates with high expression of CD122, the common beta-chain of the IL-2R and IL-15R
- TBR2 is a member of a conserved protein family that shares a common DNA-binding domain, the T-box
- T-box genes encode transcription factors involved in the regulation of developmental processes
- A similiar protein disrupted in mice is shown to be essential during trophoblast development and gastrulation
- TBR2 plays a role in brain development and is required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex.