CD271 (NGF Receptor) Monoclonal Antibody (ME20.4), eBioscience™, Invitrogen™

Description

• The MAb ME20.4 recognizes CD271, a 75 kDa type I transmembrane protein that belongs to the low-affinity neurotrophin receptor and tumor necrosis factor receptor superfamily
• CD271 is expressed by neurons, Schwann cells, melanocytes, mesenchymal stem/stromal cells, neural crest stem cells, astrocytes, oligodendrocytes, and a subset of lymphoid cells including follicular dendritic cells
• CD271 binds to the ligands NGF, BDNF, NTF3, and NTF4
• CD271 contains a death domain which induces apoptosis and regulates cell growth and proliferation through interactions with TRAF2, TRAF4, TRAF6, PTPN13, and RANBP9
• The ME20.4 MAb recognizes human, Non-human Primate, mouse, rat, sheep, rabbit, cat, dog, and pig CD271
• Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types
• Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo
• Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.