ST2 Monoclonal Antibody (12), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
ST2
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative
Gene Alias
DER4; Fit1; Fit-1; Fos-responsive gene 1 protein; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL-1 R4; IL1RL1; IL-1RL1; IL33R; IL-33R; interleukin 1 receptor like 1; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; Interleukin1 receptor like 1; interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Ly84; lymphocyte antigen 84; Protein ST2; Protein T1; sIL 33R; soluble IL 33 Receptor; soluble IL 33R; St2; ST2L; St2-rs1; ST2V; Ste2; T1; T1/ST2
Gene Symbols
IL1RL1
Isotype
IgG2b
Purification Method
Protein A
Product Type
Antibody
Clone
12
Applications
ELISA
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
Q01638
Gene ID (Entrez)
9173
Immunogen
Recombinant human IL1RL1/IL1R4 protein
Primary or Secondary
Primary
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Gene
IL1RL1
Related Products
Description
- Specificity: Human IL1RL1/IL1R4 IL-33R, also known as ST2, is a receptor for IL-33
- It is a member of the IL-1 receptor family of innate receptors
- Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33
- IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways
- This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13
- Two most common isoforms of IL-33R that result from alternative splicing are ST2L – the membrane bound form, and ST2S – the soluble form
- The membrane bound form can be released from the cell surface by proteolytic cleavage
- The soluble forms have been suggested to act as decoys dampening the IL-33 signaling
- IL-33R is primarily expressed by mast cells, basophils, and eosinophils
- In mouse, IL-33R expression has been shown on ILC2 and Th2 cells
- IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.