TIM-1 Monoclonal Antibody (12B1C8H3), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TIM-1
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative
Gene Alias
AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Gene Symbols
Havcr1
Isotype
IgG1
Purification Method
Protein A
Product Type
Antibody
Clone
12B1C8H3
Applications
ELISA
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
Q96D42
Gene ID (Entrez)
26762
Immunogen
Recombinant Human HAVCR1 protein.
Primary or Secondary
Primary
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Gene
Havcr1
Related Products
Description
- Specificity: Human HAVCR1/TIM1/KIM1 CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail
- The endogenous ligand for CD365 is Tim-4
- In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus
- The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes
- Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity
- CD365 has also been implicated in the T cell co-stimulation
- CD365 is primarily expressed in epithelial cells
- It is also highly expressed in A549, 769-P and Caco-2 and cell lines
- CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.