7240820
TGF alpha Monoclonal Antibody (D20), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TGF alpha
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Alias
EGF-like TGF; ETGF; I79_019067; LOC100009150; Protransforming growth factor alpha; RATTGFAA; TFGA; TGF a; TGF type 1; TGF a; TGFA; TGFAA; TGFalpha; TGF-alpha; TGFa; Transforming growth factor; Transforming growth factor alpha; transforming growth factor, alpha; transforming growth factor-alpha; wa1; wa-1; waved 1
Gene Symbols
TGFA
Isotype
IgG2b κ
Purification Method
Protein A/G
Product Type
Antibody
Clone
D20
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
P01135
Gene ID (Entrez)
7039
Immunogen
Glu24-Ala98 (Accession P01135), with N-terminal His Tag
Primary or Secondary
Primary
Content And Storage
-20°C
Gene
TGFA
Related Products
Description
- TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells
- It is produced by monocytes, keratinocytes, and various tumor cells
- TGF-alpha induces anchorage-independence transformation in cultured cells
- Human, murine and rat TGF-alpha are cross-species reactive
- TGFalpha (aa 50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation
- It plays a role in tumor initiation by inducing the reversible transformed phenotype.