7244917
Valproic Acid Monoclonal Antibody (VP13-615.3), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Valproic Acid
Concentration
2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative; pH 7.4
Immunogen
Valproic acid, conjugated to KLH.
Primary or Secondary
Primary
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Clone
VP13-615.3
Applications
ELISA
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Chemical
Gene Alias
C8H16O2; Depakene; Depakine; Dipropylacetic acid
Isotype
IgG1
Purification Method
Protein A
Product Type
Antibody
Related Products
Description
- MA1-10769 detects Valproic Acid
- MA1-10769 has been successfully used in ELISA applications
- The MA1-10769 immunogen is Valproic acid, conjugated to KLH
- Valproic acid, valproate sodium, and divalproex belong to the group of medicines called anticonvulsants
- They are used to control certain types of seizures in the treatment of epilepsy
- Also Valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo
- Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic center of HDACs
- Most importantly, valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients
- More over, tumor growth and metastasis formation are significantly reduced in animal experiments
- Therefore, valproic acid might serve as an effective drug for cancer therapy.