89-007-078
cleavage and polyadenylation specific factor 4, 30kDa, Mouse, Polyclonal Antibody, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-007-078-Each-of-1 | In Stock | ₹ 42,898.00 |
89-007-078 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,898.00
GST (18%): ₹ 7,721.64
Total Price: ₹ 50,619.64
Antigen
cleavage and polyadenylation specific factor 4, 30kDa
Classification
Polyclonal
Description
Mouse polyclonal antibody raised against a full-length human CPSF4 protein.
Gene
CPSF4
Gene Alias
CPSF30/NAR/NEB1
Host Species
Mouse
Quantity
50 μL
Whole Molecule
Yes
Gene ID (Entrez)
10898
Content And Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Applications
Western Blot
Conjugate
Unconjugated
Formulation
No additive
Gene Accession No.
BC003101
Gene Symbols
CPSF4
Immunogen
CPSF4 (AAH03101, 1 a.a. ∼ 244 a.a) full-length human protein.
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Serum
Related Products
Description
- Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain
- The NS1 effector domain functionally interacts with the cellular 30kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs
- In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit
- Binding of the NS1 protein to the 30kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs
- Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs
- Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene
- [provided by RefSeq] Sequence: MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPAKQRTPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ