89-018-820
glutamate receptor, metabotropic 1, Mouse, Polyclonal Antibody, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-018-820-Each-of-1 | In Stock | ₹ 30,794.00 |
89-018-820 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,794.00
GST (18%): ₹ 5,542.92
Total Price: ₹ 36,336.92
Antigen
glutamate receptor, metabotropic 1
Classification
Polyclonal
Description
Mouse polyclonal antibody raised against a partial recombinant GRM1.
Gene
GRM1
Gene Alias
GPRC1A/GRM1A/MGLUR1/MGLUR1A/mGlu1
Host Species
Mouse
Quantity
50 μL
Research Discipline
Membrane Receptors
Gene ID (Entrez)
2911
Content And Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Applications
ELISA, Western Blot
Conjugate
Unconjugated
Formulation
50% glycerol
Gene Accession No.
NM_000838
Gene Symbols
GRM1
Immunogen
GRM1 (NP_000829, 387 a.a. ∼ 486 a.a) partial recombinant protein with GST tag.
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Serum
Related Products
Description
- L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors
- Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions
- The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties
- Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C
- Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8
- Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities
- The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system
- Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions
- [provided by RefSeq Sequence: NPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQY