CDKN2A, Mouse, Clone: IMD-16, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-110-449-Each-of-1 | In Stock | ₹ 68,797.00 |
89-110-449 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 68,797.00
GST (18%): ₹ 12,383.46
Total Price: ₹ 81,180.46
Antigen
CDKN2A
Classification
Monoclonal
Conjugate
Unconjugated
Dilution
Western Blot (0.5-1 ug/mL) Immunohistochemistry (Frozen sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user.
Gene
CDKN2A
Gene Symbols
CDKN2A
Immunogen
Recombinant protein corresponding to full length human CDKN2A.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Lyophilized
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Clone
DCS-50
Description
Mouse monoclonal antibody raised against full length recombinant CDKN2A.
Formulation
Lyophilized from 1.2% sodium acetate (2mg BSA, 0.01mg sodium azide)
Gene Alias
ARF/CDK4I/CDKN2/CMM2/INK4/INK4a/MLM/MTS1/TP16/p14/p14ARF/p16/p16INK4/p16INK4a/p19
Host Species
Mouse
Purification Method
Affinity purification
Regulatory Status
RUO
Gene ID (Entrez)
1029
Content And Storage
Store at -20°C on dry atmosphere. After reconstitution with 1mL of 1.2% sodium acetate or neutral PBS to a concentration of 100μg/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Isotype
IgG1
Related Products
Description
- This gene generates several transcript variants which differ in their first exons
- At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase
- The remaining transcript includes an alternate first exon located 20kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants
- This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53
- In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control
- This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene
- [provided by RefSeq