89-110-947

ESPL1, Mouse, Clone: XJ11-4D7, Abnova™

Manufacturer: Abnova Corporation

Select a Size

Pack Size SKU Availability Price
Each of 1 89-110-947-Each-of-1 In Stock ₹ 1,09,381.00

89-110-947 - Each of 1

₹ 1,09,381.00

In Stock

Quantity

1

Base Price: ₹ 1,09,381.00

GST (18%): ₹ 19,688.58

Total Price: ₹ 1,29,069.58

Antigen

ESPL1

Classification

Monoclonal

Conjugate

Unconjugated

Dilution

Immunofluorescence (1:1000) The optimal working dilution should be determined by the end user.

Gene

ESPL1

Gene Symbols

ESPL1

Immunogen

Recombinant fusion protein corresponding to amino acids 1866-1996 of human ESPL1.

Regulatory Status

RUO

Gene ID (Entrez)

9700

Target Species

Human

Form

Liquid

Applications

Immunofluorescence

Clone

XJ11-4D7

Description

Mouse monoclonal antibody raised against partial recombinant ESPL1.

Formulation

In buffer containing 0.09% sodium azide

Gene Alias

ESP1/FLJ46492/KIAA0165/SEPARASE/SEPARIN

Host Species

Mouse

Quantity

100 μL

Primary or Secondary

Primary

Test Specificity

This antibody is specific to human separase.

Content And Storage

Store at -20°C or -80°C.Aliquot to avoid repeated freezing and thawing.

Isotype

IgG2a

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Description

  • Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance
  • In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms
  • The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 604359) in the cohesin complex
  • The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM