ALK (phospho Y1586), Rabbit anti-Human, Polyclonal Antibody, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-118-809-Each-of-1 | In Stock | ₹ 57,138.00 |
89-118-809 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 57,138.00
GST (18%): ₹ 10,284.84
Total Price: ₹ 67,422.84
Antigen
ALK
Classification
Polyclonal
Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ALK.
Formulation
In 20mM PBS, 0.15M NaCl, pH 7.2 (0.01% sodium azide)
Gene Accession No.
Q9UM73
Gene Symbols
ALK
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y1586 of human ALK.
Regulatory Status
RUO
Gene ID (Entrez)
238
Target Species
Human
Form
Liquid
Applications
ELISA, Immunohistochemistry (PFA fixed), Western Blot
Conjugate
Unconjugated
Dilution
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:4000) The optimal working dilution should be determined by the end user.
Gene
ALK
Gene Alias
CD246/Ki-1/TFG/ALK
Host Species
Rabbit
Quantity
100 μg
Primary or Secondary
Primary
Test Specificity
This antibody detects endogenous levels of ALK only when phosphorylated at tyrosine 1586.
Content And Storage
Store at 4°C for three months. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Related Products
Description
- The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs)
- The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5
- A recent study shows that the product of the NPM-ALK fusion gene is oncogenic
- The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain
- These sequences are absent in the product of the transforming NPM-ALK gene
- ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase)
- ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system
- [provided by RefSeq]