89-129-473
CDKN2A, Chicken, Biotin, Polyclonal Antibody, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-129-473-Each-of-1 | In Stock | ₹ 57,138.00 |
89-129-473 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 57,138.00
GST (18%): ₹ 10,284.84
Total Price: ₹ 67,422.84
Antigen
CDKN2A
Classification
Polyclonal
Conjugate
Biotin
Formulation
In Phosphate-Buffered Saline with 0.02% Sodium Azide.
Gene Alias
ARF/CDK4I/CDKN2/CMM2/INK4/INK4a/MLM/MTS1/TP16/p14/p14ARF/p16/p16INK4/p16INK4a/p19
Host Species
Chicken
Purification Method
Antigen affinity purification
Regulatory Status
RUO
Gene ID (Entrez)
1029
Content And Storage
Store at 4°C. For long term storage aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Isotype
IgY
Applications
Immuno-MRM (Multiple Reaction Monitoring)
Concentration
1 mg/mL
Description
Chicken polyclonal antibody against synthetic peptide of CDKN2A
Gene
CDKN2A
Gene Symbols
CDKN2A
Immunogen
A Synthetic peptide corresponding to amino acids of CDKN2A
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- This gene generates several transcript variants which differ in their first exons
- At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase
- The remaining transcript includes an alternate first exon located 20kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants
- This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53
- In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control
- This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene
- [provided by RefSeq Sequence: IDAAEGPSDIPD