89-129-500
TP53, Chicken, Biotin, Polyclonal Antibody, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-129-500-Each-of-1 | In Stock | ₹ 57,138.00 |
89-129-500 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 57,138.00
GST (18%): ₹ 10,284.84
Total Price: ₹ 67,422.84
Antigen
TP53
Classification
Polyclonal
Conjugate
Biotin
Formulation
In Phosphate-Buffered Saline with 0.02% Sodium Azide.
Gene Alias
FLJ92943/LFS1/TRP53/p53
Host Species
Chicken
Purification Method
Antigen affinity purification
Regulatory Status
RUO
Gene ID (Entrez)
7157
Content And Storage
Store at 4°C. For long term storage aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Isotype
IgY
Applications
Immuno-MRM (Multiple Reaction Monitoring)
Concentration
0.2 mg/mL
Description
Chicken polyclonal antibody against synthetic phosphopeptide of TP53
Gene
TP53
Gene Symbols
TP53
Immunogen
Synthetic phosphopeptide corresponding to amino acids of TP53
Quantity
20 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism
- p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy
- p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains
- It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor
- Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity
- Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome
- Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found
- These variants encode distinct isoforms, which can regulate p53 transcriptional activity
- [provided by RefSeq] Sequence: MEEPQSDPSVEPPL(pS)QETFSDLWK