BRCA1 (phospho S1189), Rabbit anti-Human, Polyclonal Antibody, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-134-013-Each-of-1 | In Stock | ₹ 87,220.00 |
89-134-013 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 87,220.00
GST (18%): ₹ 15,699.60
Total Price: ₹ 1,02,919.60
Antigen
BRCA1
Classification
Polyclonal
Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRCA1.
Formulation
In PBS, pH 7.2 (50% glycerol, 1% BSA, 0.02% thimerosal)
Gene Alias
BRCAI/BRCC1/IRIS/PSCP/RNF53
Host Species
Rabbit
Quantity
100 μg
Primary or Secondary
Primary
Test Specificity
This antibody detects human BRCA1 when phosphorylated at Ser1189.
Content And Storage
Store at -20°C. For long term storage store at -80°C.Aliquot to avoid repeated freezing and thawing.
Applications
Western Blot
Conjugate
Unconjugated
Dilution
Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user.
Gene
BRCA1
Gene Symbols
BRCA1
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S1189 of human BRCA1.
Regulatory Status
RUO
Gene ID (Entrez)
672
Target Species
Human
Form
Liquid
Related Products
Description
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor
- The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC)
- This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes
- This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination
- Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers
- Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene
- Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described
- A related pseudogene, which is also located on chromosome 17, has been identified
- [provided by RefSeq