89-126-714
BRCA1 (phospho S1524), Rabbit anti-Human, Polyclonal Antibody, Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-126-714-Each-of-1 | In Stock | ₹ 87,220.00 |
89-126-714 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 87,220.00
GST (18%): ₹ 15,699.60
Total Price: ₹ 1,02,919.60
Antigen
BRCA1
Classification
Polyclonal
Conjugate
Unconjugated
Dilution
Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.
Gene
BRCA1
Gene Symbols
BRCA1
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S1524 of BRCA1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (PFA fixed)
Concentration
1 mg/mL
Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRCA1.
Formulation
In PBS, pH 7.2 (0.05% sodium azide)
Gene Alias
BRCAI/BRCC1/IRIS/PSCP/RNF53
Host Species
Rabbit
Purification Method
Antigen affinity purification
Regulatory Status
RUO
Gene ID (Entrez)
672
Content And Storage
Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Related Products
Description
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor
- The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC)
- This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes
- This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination
- Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers
- Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene
- Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described
- A related pseudogene, which is also located on chromosome 17, has been identified
- [provided by RefSeq