MilliporeSigma™ Rabbit anti-Tau, AEP-cleaved (N368), Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN1703MI-Each-of-1 | In Stock | ₹ 40,633.84 |
ABN1703MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,633.84
GST (18%): ₹ 7,314.091
Total Price: ₹ 47,947.931
Antigen
Tau, AEP-cleaved (N368)
Classification
Polyclonal
Gene Accession No.
P10636
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Serum
Applications
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Formulation
Rabbit polyclonal serum with 0.05% sodium azide.
Gene Symbols
MAPT; MAPTL; MTBT1; TAU
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of human Tau, AEP-cleaved (N368).
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_005901
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
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Description
- Specifically detects Tau, AEP-cleaved (N368) in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting Microtubule-associated protein Tau (UniProt P10636; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as TAU, MAPT1, MTBTL) gene (Gene ID 4137) in human
- Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated Tau, are a common feature of aging-related neurodegenerative diseases, including Alzheimer's disease (AD)
- In addition to caspases-mediated cleavage at Asp421, Tau can also be cleaved at Asn255 and Asn368 by the lysosomal cysteine proteinase asparagine endopeptidase (AEP)
- AEP is upregulated in aged brain, as well as n human AD brain and tau P301S–transgenic mice with synaptic pathology and behavioral impairments
- AEP-mediated tau cleavage abolishes tau microtubule assembly function, induces tau aggregation and triggers neurodegeneration
- AEP knockout or functional blockage in tau P301S mice leads to a reduction of tau hyperphosphorylation, protection against memory loss, and a reduction in tau P301S–triggered pathological and behavioral defects.