ABN1728MI
MilliporeSigma™ MeCP2, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN1728MI-Each-of-1 | In Stock | ₹ 40,292.08 |
ABN1728MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
MeCP2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MECP2, AS, MRXS13, MRXSL, PPMX, RTT, AUTSX3
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This polyclonal antibody targets MeCp2 C-terminal end sequence conserved between spliced isoform A (isoform Beta) and isoform B (isoform Alpha).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing PBS with 0.03% Sodium Azide.
Gene Accession No.
P51608
Immunogen
Linear peptide corresponding to human MeCp2 C-terminal end sequence.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_004983
Target Species
Human
Related Products
Description
- Methyl-CpG-binding protein 2 (UniProt P51608; also known as MeCp-2 protein, MeCp2) is encoded by the MECP2 (also known as AS, MRXS13, MRXSL, PPMX, RTT, AUTSX3) gene (Gene ID 4204) in human
- Methyl-CpG-binding proteins that are involved in gene expression regulation by targeting methylated DNA residues in gene promoters via a conserved methyl-CpG-binding domain (MBD; a.a
- 90-162 of human MeCp2)
- Upon binding methylated CpG sites on the DNA strands, transcriptional repression domain (TRD; a.a
- 207-492) then mediates association with SIN3A to recruit histone deacetylases (HDAC)
- The TRD region also contains a nuclear localization signal (NLS) sequence (a.a
- 255-271) and a nuclear receptor co-repressor 2/NCoR2-interacting site (a.a
- 269-309)
- MeCp2 protein is found in all cells in the body, including the brain, where it is found in high concentrations in neurons and is associated with maturation of the central nervous system (CNS) and in forming synaptic contacts
- In contrast to other MBD family members, MECP2 is X-linked and subject to X chromosome inactivation
- MECP2 gene mutations are linked to Rett syndrome (RTT), a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.