MilliporeSigma™ AXL (UFO), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN897-Each-of-1 | In Stock | ₹ 45,464.76 |
ABN897 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,464.76
GST (18%): ₹ 8,183.657
Total Price: ₹ 53,648.417
Antigen
AXL (UFO)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
AXL, UFO
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody targets cytoplasmic C-terminal end region present in both spliced isoforms of human AXL (UFO) reported by UniProt (P30530). This antibody will not detect internalized portion, but not the extracellular portion of the receptor following its cleavage by ADAM10.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P30530
Immunogen
GST-tagged human AXL (UFO) C-terminal end fragment lacking most of the kinase domain sequence.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_068713
Target Species
Human
Related Products
Description
- Sterol regulatory element-binding protein cleavage-activating protein (UniProt P97260; also known as SCAP, SREBP cleavage-activating protein) is encoded by the SCAP gene (Gene ID 100689048) in hamster species
- SCAP mediates the activation of membrane-bound transcription factors SREBPs (sterol-regulatory element binding proteins) for transcribing genes encoding cholesterol biosynthetic enzymes
- In sterol-deprived cells, SCAP escorts SREBPs from ER to Golgi, where active fragments of SREBPs are released from membrane by proteolysis
- Sterol accumulation inuduces a negative regulatory mechanism, where SCAP becomes bound by Insigs and trapped in the ER, preventing further delivery of SREBPs to the Golgi for proteolytic release
- SCAP spans the ER membrane eight times (a.a
- 19-39, 280-300, 313-333, 345-365, 402-422, 424-444, 519-539, 709-729) with