ABN898MI
MilliporeSigma™ BMP2, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN898MI-Each-of-1 | In Stock | ₹ 45,463.87 |
ABN898MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,463.87
GST (18%): ₹ 8,183.497
Total Price: ₹ 53,647.367
Antigen
BMP2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BMP2, BMP2A
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody targets a region present in Prepro-, pro-, and mature human BMP2.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P12643
Immunogen
GST-tagged recombinant protein composed of the propeptide C-terminal region and the mature human BMP2 N-terminal region.
Quantity
200 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_001191
Target Species
Human
Related Products
Description
- Bone morphogenetic protein 2 (UniProt: P12643; also known as BMP-2, BMP-2A, Bone morphogenetic protein 2A) is encoded by the BMP2 (also known as BMP2A) gene (Gene ID 650) in human
- BMP2 is a member of the transforming growth factor-beta (TGF-beta) superfamily
- It is synthesized as a 60kDa precursor that is processed in the secretory pathway to a small 18kDa monomer; 2 monomers then associate to form the active homodimer, which binds to its receptor
- BMP2 can induce bone formation and regeneration during early embryonic development
- It is also involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction
- BMP2 is known to induce cartilage and bone formation and stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway
- BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A, which leads to increased expression of ATF4 that plays a critical role in osteoblast differentiation.