ABS1616MI
MilliporeSigma™ Rabbit anti-CGI-58, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1616MI-Each-of-1 | In Stock | ₹ 40,633.84 |
ABS1616MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,633.84
GST (18%): ₹ 7,314.091
Total Price: ₹ 47,947.931
Antigen
CGI-58
Classification
Polyclonal
Gene Accession No.
Q9DBL9
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse
Form
Serum
Applications
Immunocytochemistry, Western Blot
Formulation
Rabbit polyclonal serum with 0.05% sodium azide.
Gene Symbols
Abhd5
Immunogen
His-tagged recombinant protein corresponding to mouse CGI-58.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_080455
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Related Products
Description
- Specifically detects CGI-58 in Mouse samples, and it is validated for Immunocytochemistry, Western Blotting 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (EC:2.3.1.51; UniProt Q9DBL9; also known as Abhydrolase domain-containing protein 5, CGI-58, Comparative gene identification-58, Lipid droplet-binding protein CGI-58) is encoded by the Abhd5 (also known as CDS, IECN5, NCIE2, 1300003D03Rik, 2010002J10Rik) gene in murine species (Gene ID 67469)
- The comparative gene identification-58 (CGI-58) functions as a cofactor of adipose triglyceride lipase/ATGL-mediated triacylglycerol (TG) hydrolytic activity, which is essential for efficient catabolism of cellular TG stores
- Mutations in the genes coding for ATGL or CGI-58 in humans cause neutral lipid storage disease characterized by TG accumulation in multiple tissues
- CGI-58 gene mutations provoke severe ichthyosis and hepatosteatosis in humans and mice
- Mice lacking CGI-58 exclusively in muscle (CGI-58KOM) show TG accumulation in both skeletal and cardiac muscle tissues and develop severe cardiac steatosis and cardiomyopathy as a result of impaired TG catabolism and mitochondrial fatty acid oxidation
- Immunocytochemistry analysis reveals diffuse cytoplasmic staining of CGI-58 in 3T3-L1 preadipocytes, while CGI-58 staining is found exclusively on the surface of lipid droplets in differentiated 3T3-L1 adipocytes
- CGI-58 binds to lipid droplets by interacting with perilipin C-terminal sequence, while activation of cellular PKA disperses CGI-58 localization from the lipid droplets to cytosol.