STRN3, Rabbit anti-Mouse, Human, Polyclonal, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS209925UG-Each-of-1 | In Stock | ₹ 16,643.00 |
ABS209925UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,643.00
GST (18%): ₹ 2,995.74
Total Price: ₹ 19,638.74
Antigen
STRN3
Classification
Polyclonal
Dilution
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected STRN3 in HeLa cells.
Gene Alias
Cell cycle autoantigen SG2NA;S/G2 antigen
Host Species
Rabbit
Molecular Weight of Antigen
∽87 kDa observed; 87.21 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity
25 μg
Research Discipline
Signaling
Test Specificity
This rabbit polyclonal antibody detect Striatin-3 in human and murine cells. It targets an epitope within 17 amino acids from the N-terminal half.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Conjugate
Unconjugated
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
STRN3;GS2NA;SG2NA
Immunogen
KLH-conjugated linear peptide corresponding to 17 amino acids from the N-terminal half of human Striatin-3. The immunogen sequence is conserved in both alpha and beta isoforms.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse, Human
Form
Purified
Related Products
Description
- Anti-STRN3, Cat
- No
- ABS2099, is a rabbit polyclonal antibody that detects Striatin-3 and has been tested for use in Immunocytochemistry and Western Blotting
- Striatin-3 (UniProt: Q13033; also known as Cell cycle autoantigen SG2NA, S/G2 antigen) is encoded by the STRN3 (also known as GS2NA, SG2NA) gene (Gene ID: 29966) in human
- Striatin-3 is a calmodulin-binding protein that bonds calmodulin a calcium dependent manner and may function as scaffolding or signaling protein
- Two isoforms of Striatin-3 have been reported that are produced by alternative splicing
- Its calmoduln-binding region is located within amino acids 166-183
- It also contains a caveolin-binding region (aa 71-79), six WD repeats, and a coiled coil region (aa 77-136)
- The coiled coil domain and the PP2A subunit can form a stable core complex with a 2:2 stoichiometry
- The coiled coil domain of striatin-3 is a novel type of PP2A regulatory subunit that functions as a scaffold for the assembly of the STRIPAK complex
- PP2A and certain kinases, such as germinal central kinase III (GCKIII) interact with striatin to form striatin-interacting phosphatase and kinase (STRIPAK) complex that are known to regulate multiple cellular events
- Wild-type striatin-3 is shown to strongly suppress apoptosis in Jurkat cells induced by the GCKIII kinase MST3
- However, mutant forms of striatin-3 fail to exhibit this effect
- (Ref.: Lu, Q., et al
- (2004)
- Proc
- Natl
- Acad
- Sci
- USA 101(49); 17126-17131; Chen, C., et al
- (2014)
- J
- Biol
- Chem
- 289(14); 9651-61).