ABT257MI
MilliporeSigma™ Rabbit anti-Pro-Collagen Type I, A1/COL1A1, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABT257MI-Each-of-1 | In Stock | ₹ 42,947.84 |
ABT257MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,947.84
GST (18%): ₹ 7,730.611
Total Price: ₹ 50,678.451
Antigen
Pro-Collagen Type I, A1/COL1A1
Classification
Polyclonal
Gene Accession No.
P02452
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse
Applications
Flow Cytometry, Immunohistochemistry, Western Blot
Formulation
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Gene Symbols
COL1A1
Immunogen
Linear peptide corresponding to sequence derived from human Pro-Collagen Type I, A1/COL1A1 C-terminal propeptide region.
Quantity
100 μL
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_000079
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Related Products
Description
- Specifically detects Pro-Collagen Type I, A1/COL1A1 in Human, Mouse samples, and it is validated for Flow Cytometry, Immunohistochemistry, Western Blotting Collagen alpha-1(I) chain (UniProt P02452; also known as Alpha-1 type I collagen) is encoded by the COL1A1 gene (Gene ID 1277) in human
- Collagen is the major component of the extracellular matrix (ECM) and form the fibrils of tendons, ligaments, and bones
- Type I collagen consists of two alpha I chains and one alpha 2 chain
- Alpha-1 type I collagen is initially produced as an 1464-amino acid prepro-form with a signal peptide sequence (a.a
- 1-22) and two propeptide sequences (a.a
- 23-161 and a.a
- 1219 –1464), the removal of which yields the mature alpha-1(I) chain
- The mature alpha-1(I) chain is composed mostly of a large triple-helical region (a.a
- 179-1192) sandwiched between two nonhelical segments known as the N-terminal telopeptide (a.a
- 162-178; numbering based on the prepro-form) and the C-terminal telopeptide (a.a
- 1193-1218; numbering based on the prepro-form)
- Collagen can be extracted from tissue via either enzymatic or non-enzymatic means
- Collagen extracted using the proteolytic enzyme pepsin corresponds to the large triple-helical region, referred to as atelocollagen because both the N- and C-terminal telopeptides have been cleaved off by pepsin
- On the other hand, collagen preparations obtained with non-enzymatic means (e.g
- by acid extraction) have the intact telopeptides at both ends.