STEP Monoclonal Antibody (23E5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | AMPA6746-Each-of-1 | In Stock | ₹ 47,036.50 |
AMPA6746 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
STEP
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.09% sodium azide
Gene Accession No.
P35234, P54829, P54830
Gene Symbols
PTPN5
Immunogen
A synthetic peptide of STEP46 (amino acids 57-74: MCTPGCNEEGFGYLVSPR)
Regulatory Status
RUO
Gene ID (Entrez)
19259, 29644, 84867
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
23E5
Conjugate
Unconjugated
Gene
PTPN5
Gene Alias
FLJ14427; Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched); protein-tyrosine phosphatase striatum-enriched; protein-tyrosine-phosphatase non-receptor 5; PTN5; PTP STEP; PTPN 5; PTPN5; PTPSTEP; STEP; STEP61; striatal-enriched protein tyrosine phosphatase; striatum-enriched protein-tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 5
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Suggested positive control: rat brain
- Reversible phosphorylation of tyrosine residues is a key regulatory mechanism for numerous cellular events such as proliferation, differentiation, gene expression and migration
- Abnormalities in tyrosine phosphorylation play a role in the pathogenesis of numerous inherited or acquired human diseases from cancer to immune deficiencies
- There are at least 107 genes coding for PTPs (protein tyrosine phosphatases) in the human genome
- All known PTPs contain a highly conserved 12 amino acid catalytic domain and are further distinguished on the basis of additional structural motifs
- The receptor-like PTPs exhibit an extracellular domain, a single transmembrane and one or two intracellular phosphatase domains
- The nonreceptor cytoplasmic PTPs contain a single phosphatase domain and additional amino acid sequences that are homologous to motifs found in other classes of proteins
- Protein tyrosine phosphatases PTPN5 (STEP), PTPRR and PTPN7 comprise a family of phosphatases that specifically inactivate MAPKs (mitogen-activated protein kinases)
- There are multiple forms of STEP in the adult rat brain which show differential enrichment in brain regions implicated in aspects of cognitive, affective, and motor behaviors
- Some of the STEP isoforms are generated through alternative splicing of a single STEP gene and each has unique intracellular targets and functions.