Phospho-alpha Synuclein (Ser129) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | APP4686-Each-of-1 | In Stock | ₹ 49,439.50 |
APP4686 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,439.50
GST (18%): ₹ 8,899.11
Total Price: ₹ 58,338.61
Antigen
Phospho-alpha Synuclein (Ser129)
Classification
Polyclonal
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
O55042, P37377, P37840
Gene Symbols
SNCA
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser129 of rat SNCA conjugated to KLH
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Conjugate
Unconjugated
Gene
SNCA
Gene Alias
Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20617, 29219, 6622
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- This antibody is predicted to react with bovine, canine, human, mouse and non-human primate based on 100% sequence homology
- This antibody is specific for the ∽15 kDa alpha-synuclein protein phosophorylated at Ser129
- Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide
- Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein
- These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking
- Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways
- Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease
- Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease
- Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene
- Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.