Survivin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | APPA6836-Each-of-1 | In Stock | ₹ 52,332.00 |
APPA6836 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,332.00
GST (18%): ₹ 9,419.76
Total Price: ₹ 61,751.76
Antigen
Survivin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Birc5
Gene Alias
AAC-11; AP14; Api4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; EPR-1; Iap4; inhibitor of apoptosis; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100527953, 100689366, 11799, 332, 442936, 493835, 64041
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Applications
ChIP Assay, ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
E3SCZ8, O15392, O70201, Q6I6F4, Q8I009, Q9JHY7
Gene Symbols
Birc5
Immunogen
Recombinant human survivin, full-length.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Canine, Feline, Guinea Pig, Hamster, Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- For IHC, prior antigen retrieval (pressure cooking) is recommended for cytoplasmic and nuclear detection of Survivin
- Suggested positive control: Hela whole cell extract, antigen standard for BIRC5 (transient overexpression lysate)
- Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family
- The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues
- IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain
- The encoded proteins also lack a C-terminus RING finger domain
- Gene expression is high during fetal development and in most tumors yet low in adult tissues
- Antisense transcripts are involved in the regulation of survivin’s gene expression
- Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner
- At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics
- Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis
- Survivin may counteract a default induction of apoptosis in G2/M phase
- Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury
- Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein)
- Survivin might affect regulation of neural cell proliferative responses after brain injury
- At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined
- The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.