BDB551186
CD209 Mouse anti-Human, Unlabeled, Clone: DCN46, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB551186-Each-of-1 | In Stock | ₹ 31,639.50 |
BDB551186 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,639.50
GST (18%): ₹ 5,695.11
Total Price: ₹ 37,334.61
Antigen
CD209
Classification
Monoclonal
Concentration
0.5mg/mL
Description
DC-SIGN
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Applications
Flow Cytometry
Clone
DCN46
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Human Monocyte Derived DC Cells
Quantity
0.1 mg
Research Discipline
Immunology
Target Species
Human
Isotype
IgG2b κ
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Description
- The DCN46 antibody specifically binds to dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN or CD209), a type-II membrane protein of approximately 44 kDa with a mannose-binding C-type lectin domain
- It is highly expressed on dendritic cells in mucosal tissues
- Its sequence is identical to the HIV-1 envelope gp120-binding C-type lectin, and reports suggest that DC-SIGN binds to HIV-1 gp120 and effectively transmits infectious HIV-1 to resting T lymphocytes expressing CD4 and chemokine receptors
- The C-type lectin domain of DC-SIGN is also capable of binding other pathogenic viruses, bacteria, and parasites
- Reports also suggest that DC-SIGN enables the highly efficient migration of dendritic cells from blood into the tissues
- It can interact with ICAM-2, which has a similar sequence as ICAM-3, and is abundantly expressed on vascular and lymphoid endothelium
- Thus, DC-SIGN mediates dendritic cells rolling and transendothelial migration, and its interaction with ICAM-2 is essential to specific migratory functions of dendritic cells.