BDB551244
Caspase-8 Mouse anti-Human, Unlabeled, Clone: 4-1-20, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB551244-Each-of-1 | In Stock | ₹ 25,454.00 |
BDB551244 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,454.00
GST (18%): ₹ 4,581.72
Total Price: ₹ 30,035.72
Antigen
Caspase-8
Classification
Monoclonal
Concentration
0.5mg/mL
Description
FLICE, MACH-1, Mch5
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Applications
Western Blot
Clone
4/1/2020
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Human caspase-8 recombinant protein
Quantity
50 μg
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG1 κ
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Description
- Caspase-8 (FLICE/MACH-1) is a 55 kDa cytosolic protein with homology to the CD95/Fas-associated signal transducer, FADD/MORT-1, as well as to other caspase (ICE/Ced-3) cysteine proteases
- The N-terminal region of caspase-8 contains an amino acid sequence, termed the death domain, that facilitates caspase-8-FADD direct interaction
- FADD therefore acts as an adapter molecule, allowing caspase-8 to become recruited to the cytoplasmic region of Fas following receptor activation
- Viral proteins (v-FLIPS) which inhibit recruitment and activation of caspase-8 have been isolated
- Caspase-8 is produced as a proenzyme (55/50 kDa doublet) which upon receptor aggregation is proteolytically cleaved into smaller subunits of 40/36 (doublet), and 23 kDa
- Overexpression of caspase-8 is sufficient to induce apoptosis in certain cell lines (e.g., MCF-7) and this phenotype is blocked by overexpression of the caspase-3 protease inhibitor, CrmA
- The antibody recognizes both the proform of human caspase-8 (55/50 kDa doublet) as well as the cleaved form (40/36 kDa doublet) on SDS/PAGE
- Full-length recombinant human caspase-8 protein was used as immunogen.