BDB552467
TNF Mouse anti-Human, NA/LE, Unlabeled, Clone: MABTNF-A5, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB552467-Each-of-1 | In Stock | ₹ 40,406.00 |
BDB552467 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,406.00
GST (18%): ₹ 7,273.08
Total Price: ₹ 47,679.08
Antigen
TNF
Classification
Monoclonal
Concentration
1.0mg/mL
Formulation
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Immunogen
Recombinant human TNF protein
Quantity
0.5 mg
Research Discipline
Immunology
Target Species
Human
Isotype
IgG2a κ
Applications
Neutralization
Clone
MABTNF-A5
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
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Description
- The MABTNF-A5 antibody, formerly known as 5N, reacts with human tumor necrosis factor, TNF (aka, TNF-α and TNFSF2)
- TNF is a multifunctional cytokine involved in a variety of immune and inflammatory responses including hemorrhagic necrosis of tumors, septic shock, fever and autoimmune diseases
- TNF can regulate the growth and differentiation of many different cell types
- It is produced by different activated cell types including macrophages, T lymphocytes, NK cells, dendritic cells, endothelial cells, peripheral blood leukocytes, osteoblasts, astrocytes, mast cells, Kupffer cells, smooth muscle cells, fibroblasts and certain tumor cells
- TNF exists in two biologically active forms, i.e., transmembrane and soluble forms
- Upon activation, cells express transmembrane TNF glycoproteins that associate as homotrimeric complexes
- After enzymatic cleavage, the extracellular region of membrane TNF sheds as a soluble homotrimer
- The biologically active form of TNF has been reported to be a trimer
- The immunogen used to generate the MABTNF-A5 hybridoma was purified recombinant human TNF
- This is an extraordinarily potent neutralizing antibody that is reportedly also useful for ELISA measurements of human TNF
- Host Species: Mouse Clone: MABTNF-A5 Isotype: IgG2a κ Species Reactivity: Human Immunogen: Recombinant human TNF protein Functional Assay, Neutralization