IL-12 Receptor β2 Hamster anti-Mouse, Unlabeled, Clone: HAM10B9, BD

Description

• Description The HAM10B9 antibody reacts with the β2subunit (IL-12Rβ2), of the mouse IL-12 receptor complex
• The IL-12Rβ2 subunit associates with a β1 subunit to form a heterodimeric IL-12 receptor complex
• Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity
• The IL-12Rβ1 subunit interacts primarily with IL-12 p40 whereas the IL-12R β2 binds both to IL-12 p40 and IL-12 p35
• IL-12Rβ1 is required for high affinity binding of IL-12 but IL-12R β2 is required for signaling
• The cytoplasmic regions of the β1 and β2 subunits contain the box 1 and box 2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR
• Naive T cells do not express IL-12R but both IL-12R subunits can be induced on T cells by antigenic stimulation
• The IL12R is also expressed on activated NK cells
• Th1 cells express both IL-12R subunits while Th2 cells lose the β2 subunit during differentiation
• The HAM10B9 antibody was generated by immunizing hamsters with mouse IL-12Rβ2 transfectants
• Host Species: Hamster Clone: HAM10B9 Isotype: IgG1 κ Species Reactivity: Mouse Immunogen: Mouse IL-12Rβ2 transfectants Flow Cytometry