BDB553147
CD62L Rat anti-Mouse, NA/LE, Unlabeled, Clone: MEL-14, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB553147-Each-of-1 | In Stock | ₹ 32,040.00 |
BDB553147 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,040.00
GST (18%): ₹ 5,767.20
Total Price: ₹ 37,807.20
Antigen
CD62L
Classification
Monoclonal
Concentration
1.0mg/mL
Description
Sell; L-selectin; LECAM-1; LAM-1; Lnhr; Ly-22; Ly-m22; Lyam-1
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Applications
Flow Cytometry
Clone
MEL-14
Conjugate
Unconjugated
Formulation
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Immunogen
C3H/eb mouse B lymphoma 38C-13
Quantity
0.5 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2a κ
Related Products
Description
- The MEL-14 monoclonal antibody specifically binds to CD62L (L-selectin), a 95 kDa (on neutrophils) or 74 kDa (on lymphocytes) receptor with lectin-like and Epidermal Growth Factor-like domains
- In the mouse, L-selectin is detected on most thymocytes, with the highest levels of expression on an immunocompetent subset and a population of dividing progenitor cells, and on peripheral leukocytes, including subsets of B and T lymphocytes, neutrophils, monocytes, and eosinophils
- This member of the selectin adhesion molecule family appears to be required for lymphocyte homing to peripheral lymph nodes and to contribute to neutrophil emigration at inflammatory sites
- L-selectin is rapidly shed from lymphocytes and neutrophils upon cellular activation; metalloproteinases may mediate the release of CD62L ectodomains from the cell surface
- The level of CD62L expression, along with other markers, distinguishes naive, effector, and memory T cells
- L-selectin binds to sialytaed oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes
- In vitro studies have demonstrated that CD34, GlyCAM-1, and MAdCAM-1, all recognized by mAb MECA-79 (anti-mouse PNAd Carbohydrate Epitope, Cat
- No
- 553863), may be ligands for CD62L
- MEL-14 mAb blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and late stages of leukocyte rolling.