BDB553656
CD154 Hamster anti-Mouse, Unlabeled, Clone: MR1, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB553656-Each-of-1 | In Stock | ₹ 29,904.00 |
BDB553656 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 29,904.00
GST (18%): ₹ 5,382.72
Total Price: ₹ 35,286.72
Antigen
CD154
Classification
Monoclonal
Concentration
0.5mg/mL
Description
CD40 Ligand, gp39
Host Species
Hamster
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Applications
Flow Cytometry
Clone
MR1
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Activated mouse Th1 clone D1.6
Quantity
0.5 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG κ3
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Description
- The MR1 antibody reacts with CD154 (CD40 Ligand, gp39), an accessory molecule expressed on activated T helper (CD4+) lymphocytes
- CD154 has also been detected on other types of leukocytes, including CD8+ T cells, medullary thymocytes, activated CD4+ NK-T cells, and human NK cells
- CD154 plays an important role in costimulatory interactions between T and B lymphocytes and between antigen-presenting cells and lymphocytes, regulating the immune response at multiple levels
- MR1 mAb inhibits in vitro activation of B lymphocytes by T helper cells by blocking interaction of gp39 with CD40
- In vitro interactions of T cells and antigen-presenting cells can also be blocked by the MR1 antibody
- In vivo treatment with MR1 antibody blocks the development of experimental autoimmune disease, inhibits formation of germinal centers and generation of memory B cells, reduces T-lymphocyte responses to allogeneic cells and allografts, prevents intrathymic deletion of self-reactive T lymphocytes, and disrupts antigen-specific T-cell responses.