BDB554234
Bcl-2 Hamster anti-Human, FITC, Clone: 6C8, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB554234-Each-of-1 | In Stock | ₹ 34,532.00 |
BDB554234 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,532.00
GST (18%): ₹ 6,215.76
Total Price: ₹ 40,747.76
Antigen
Bcl-2
Classification
Monoclonal
Conjugate
FITC
Immunogen
Human Bcl-2 Recombinant Protein, Keyhole limpet hemocyanin
Quantity
100 Tests
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG
Applications
Flow Cytometry
Clone
6C8
Host Species
Hamster
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- Programmed cell death (apoptosis) is a normal physiologic process which occurs during embryonic development as well as in maintenance of tissue homeostasis
- The apoptotic program is characterized by certain morphological features
- These include changes in the plasma membrane such as loss of membrane asymmetry and attachment, a condensation of the cytoplasm and nucleus, and internucleosomal cleavage of DNA
- In the final stages, the dying cells become fragmented into “apoptotic bodies” which are rapidly eliminated by phagocytic cells without eliciting significant inflammatory damage to surrounding cells
- Members of the Bcl-2 family play a major role in regulating the cellular response to apoptotic signals
- Bcl-2 is considered to be a novel proto-oncogene because it blocks apoptosis in many cell types
- Bcl-2 is thought to provide selective survival advantage for cells by blocking apoptosis and thus may contribute to tumorigenesis
- Bcl-2 is a 26 kDa intracellular, integral membrane protein found primarily in the nuclear envelope, endoplasmic reticulum and outer mitochondrial membrane.