BDB554254
CD95 Hamster anti-Mouse, NA/LE, Unlabeled, Clone: JO2, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB554254-Each-of-1 | In Stock | ₹ 38,982.00 |
BDB554254 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,982.00
GST (18%): ₹ 7,016.76
Total Price: ₹ 45,998.76
Antigen
CD95
Classification
Monoclonal
Concentration
1.0mg/mL
Description
Apo-1; Apt1; Fas; FASLG receptor; lpr; TNFR6; Tnfrsf6; TNR6
Host Species
Hamster
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Applications
Flow Cytometry
Clone
JO2
Conjugate
Unconjugated
Formulation
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Immunogen
WR19L mouse lymphoma cells transformed with recombinant mouse Fas
Quantity
0.5 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2
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Description
- Fas antigen, CD95, is a 45kDa cell-surface protein which can mediate apoptosis
- It belongs to the TNF (tumor necrosis factor)/NGF receptor family
- Expression of Fas has been described in the thymus, liver, heart, lung and ovary
- Fas plays an important role in the apoptotic process that takes place during development
- Monoclonal antibodies recognizing Fas such as Jo2 have cytolytic activity on cells expressing Fas
- The cell death stimulated by Fas antibodies is characteristic of apoptosis and suggests that the lethal effects are a result of interaction of antibody with a functional Fas antigen as opposed to complement-mediated lysis
- The Jo2 antibody recognizes mouse Fas
- The Jo2 antibody shows cytolytic activity against cell lines expressing mouse Fas by inducing apoptosis
- Intraperitoneal injections of Jo2 mAb have been shown to kill mice and induce apoptotic hepatocyte death
- Jo2 mAb immunoprecipitates mouse Fas as a 45kDa band from W4 cells
- W4 cells are WR19L mouse lymphoma cells transformed with mouse Fas
- The difference between the observed MW of Fas and that deduced from its amino acid sequence (Mr 34,971) may be due to glycosylation.