CD132 Rat anti-Mouse, Biotin, Clone: TUGM2, BD

Description

• The TUGm2 antibody reacts with Mouse CD132 which is also known as the common γ subunit (γc)
• The γc chain subunit is shared by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptor complexes
• The γc receptor is expressed constitutively at low levels by most lymphocytes, myeloid cells, embryonic thymocytes, and lymphoid cell lines
• The γc receptor is a 75-80 kD transmembrane glycoprotein which mediates signal transducing activities of cytokine receptor complexes with which it is associated
• TUGm2 antibody can significantly block the binding of and proliferative response to IL-4 by CTLL-2 cells
• It can also inhibit binding to high-affinity IL-2 receptors expressed by CTLL-2 cells
• By itself, the TUGm2 antibody reportedly fails to significantly inhibit CTLL-2 proliferative responses to IL-2
• However, when added along with TM-β1 (Cat
• No
• 553359), specific for the mouse IL-2Rβ chain, TUGm2 was shown to synergistically reduce IL-2-driven CTLL-2 proliferative responses
• TUGm2 can reduce the IL-7-induced proliferation of Con A-activated mouse splenocytes and the IL-7 responsive pre-B cell line, IxN/2b
• This antibody is routinely tested by flow cytometric analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.