BDB551973
CD212 Mouse anti-Mouse, Biotin, Clone: 114, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB551973-Each-of-1 | In Stock | ₹ 30,438.00 |
BDB551973 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,438.00
GST (18%): ₹ 5,478.84
Total Price: ₹ 35,916.84
Antigen
CD212
Classification
Monoclonal
Concentration
0.5mg/mL
Description
IL-12 Receptor β1 chain
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
114
Conjugate
Biotin
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
IL-12Rβ1 Transfected Cell Line
Quantity
0.1 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2a κ
Related Products
Description
- The 114 antibody reacts with mouse CD212 (the β1 subunit of IL-12Rβ1), originally termed IL-12Rβ, of the mouse IL-12 receptor complex
- The IL-12Rβ1 subunit associates with a β2 subunit to form a heterodimeric IL-12 receptor complex
- Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity
- The IL-12Rβ1 subunit interacts primarily with IL-12 p40 whereas the IL-12Rββ1 has more recently been described to bind IL-23, a heterodimer formed of the p40 subunit from IL-12, and p19
- The cytoplasmic regions of the β1 and β2 subunits contain the box1 and box2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR
- IL-12Rβ1 are primarily expressed by activated T cells and NK cells
- Experiments with IL-12Rβ1 deficient mice have shown that IL-12Rβ1 is necessary for mouse T and NK cell responsiveness to IL-12 p75
- The 114 antibody was generated by immunizing IL-12Rβ1 deficient mice of (129 x BALB/c)F1 background with mouse Ba/F3 cells that were stably transfected with IL-12Rβ1