BDB557451
CD244.2 Mouse anti-Mouse, Unlabeled, Clone: 2B4, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB557451-Each-of-1 | In Stock | ₹ 14,596.00 |
BDB557451 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 14,596.00
GST (18%): ₹ 2,627.28
Total Price: ₹ 17,223.28
Antigen
CD244.2
Classification
Monoclonal
Concentration
0.5mg/mL
Description
2B4 B6 Alloantigen
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Applications
Flow Cytometry
Clone
2B4
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
rIL-2-propagated NK1.1+ cells from C57BL/6 mice
Quantity
0.1 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2b κ
Related Products
Description
- CD244 is a member of the CD2 subset of the immunoglobulin superfamily (CD2 IgSF)
- It is expressed on all natural killer (NK) cells, IL-2-activated NK (LAK) cells, committed progenitors of NK cells, and a subset of T lymphocytes which mediate non-MHC-restricted cytoxicity, including dendritic epidermal T cells
- The 2B4 antibody reacts with CD244.2, the 2B4 alloantigen which is expressed on C57BL/6 and C58/J mice, but not in most strains tested (A/J, AKR, BALB/c, CBA/J, CBA/N, C3H/He, C57BR, DBA/1, DBA/2, NZB, SJL/J, 129)
- At least two isoforms of CD244.2 protein, products of alternative splicing of hnRNA, are expressed on IL-2-activated C57BL/6 NK cells
- They differ only in their cytoplasmic domains; with 2B4L (150-aa cytoplasmic tail) having inhibitory activity and 2B4S (93-aa tail) being stimulatory
- The extracellular domain of CD244 is a ligand for another CD2 IgSF member, CD48
- 2B4 antibody activates lytic and secretory functions of IL-2-cultured NK cells and CD244.2+ T cells.