Stat2 (pY690) Mouse anti-Human, Unlabeled, Clone: 7A/STAT2 (PY690), BD

Description

• Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors
• Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation
• Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes
• Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner
• Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor
• Stat2 is a 113kDa protein having approximately 40% homology with Stat1a
• Stat2 interacts with Stat1 for the efficient activation of Stat1 in response to IFN-α, which is essential for normal transcriptional activity of the ISGF3 complex
• Stat2 phosphorylation at the tyrosine 690 residue (Y690) after IFN-α activation can occur independently of Stat1, but the localization and nuclear stability of phosphorylated Stat2 is dependent on Stat1
• The 7a/Stat2 monoclonal antibody recognizes the phosphorylated Y690 of human Stat2
• Host Species: Mouse Clone: 7a Isotype: IgG1 κ Species Reactivity: Human Immunogen: Phosphorylated Human Stat2 Peptide Western Blotting